Premature ovarian failure - Restore Health Clinic

Premature Ovarian Failure (POF)

Premature ovarian failure (POF), also known as primary ovarian insufficiency, is a condition where the ovaries stop functioning normally before age 40. This results in irregular periods or missed periods, reduced fertility, and menopause-like symptoms like hot flashes, night sweats, vaginal dryness, and mood changes.

Some key facts about POF:

• It affects roughly 1% of women under age 40.
• The causes are often unknown, but can include autoimmune disorders, genetics, chemotherapy treatment, pelvic radiation, or infections.
• Women with POF typically have low estrogen levels but may still ovulate occasionally. About 5-10% become pregnant after diagnosis.
• Symptoms besides menstrual changes include fatigue, poor sleep, difficulty concentrating, decreased sex drive, and emotional issues like depression.
• There are no proven ways to restore normal ovarian function, but hormone replacement therapy (HRT) with estrogen/progestin can help manage symptoms. Doctors also advise optimizing bone health and emotional wellbeing.
• Women with POF have an increased risk for heart disease, osteoporosis, infertility, and other issues related to estrogen deficiency later in life. Regular checkups are important.

How is POF diagnosed? Blood tests for follicle stimulating hormone (FSH) and estrogen levels can confirm abnormally low ovarian reserve and egg production. Pelvic ultrasounds and chromosome testing help rule out other causes.

What is the treatment outlook? While the ovaries can't be revived, symptoms can be managed for decades with HRT started at diagnosis. This helps maintain bone, brain, heart, and sexual health. Emotional support is also beneficial.

Can pregnancy still occur? Pregnancy rates are reduced, but some women conceive despite POF, especially within the first few years after periods stop. If childbearing is desired, seeing a fertility specialist at Restore Health Clinic to discuss egg donation or other options is recommended.

So in summary, POF causes the ovaries to fail well before normal menopause age. It's a challenging diagnosis, but women can still live full, healthy lives by managing risks and symptoms under the care of knowledgeable doctors. There are even chances for pregnancy in some cases. Continuing research provides hope that improved therapies and solutions may emerge in the future.